Objective To prepare and evaluate Saponins PD loaded Eudragit L100 nanoparticles (SPD-LlOO-NPs). Methods The SPD-LlOO-NPs were prepared by modified quasiemulsion solvent diffusion technique. Taking particle size, entrapment efficiency (EE) and polydisperse index (PI) as comprehensive indexes, the orthogonal test design was used to optimize the preparation process. Fourier transform infrared spectrometer (FT-IR), differential scanning calorimetry(DSC) and X-ray diffraction (XRD) were applied to evaluate nanoparticle; and in vitro release was investigated. Results Novel nanoparticles were spherical, average in particle size(65.2 ±1. 6)nm, EE (99. 13 ±. 20)% , PI(0. 384 ±. 008). The release of SPD significantly depended on the pH conditions. Conclusion SPD-LlOO-NPs have high EE and homogeneous size distribution. The effect of drug sustained release of nanoparticles is significant.
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