Objective To observe anticoagulation effect of dabigatran instead of warfarin on patients undergoing percutaneous coronary intervention (PCI) and valve replacement. Methods Sixty-six patients underwent valve operation as well as PCI . They were randomly divided into 3 groups as dabigatran group (15 cases) ,low dose warfarin plus aspirin group (24 cases, ) and ordinary dose warfarin plus aspirin and polivy group (27 cases). Incidence rate of thrombosis, bleeding events and coagulation function were e-valuated by single factor analysis . Clinical symptom and sign were received. Comparision of findings was made statistically. Results Comparing two control groups, there was no significant difference in incidence rate of thrombosis (both P > 0.05 ) , observed for the research group, however there was similar incidence rate of bleeding events at discharge for the research group and during follow-up which was compared with the control group 1(4. 6% vs 4. 17% ,P > 0. 05 ) , and it was lower than that in the control group 2 (22.2% ,P <0.01). That meant in the dabigatran group there was good anticoagulation effect on patients who had complex potential anticoagulation requirement. Conclusion Single usage of dabigatran can get good anticoagulation for patients undergoing PCI and valve replacement to replace combining warfarin with aspirin.
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NSTL
维普
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