Objective To investigate correlation of the angiotensinogen(AGT) polymorphism, elderly hypertension and elderly patients with hypertension and diabetes. Methods The analysis of polyme-rase chain reaction (PCR) and restriction fragment length polymorphism on 60 cases in the healthy elderly control group, 105 cases in the elderly hypertensive group, 38 cases in the elderly patients with hypertension and diabetic group and by means of using M235T polymorphism detection. Results The frequency of MT and TT genotype and T allele frequency in the group of patients with elderly hypertension were 0.371, 0.457 and 0.643 respectively and in the group of elderly patients with hypertension and diabetes were 0. 289,0.632 and 0.776 respectively. Both were significantly higher than those in the healthy elderly control group which were 0.167,0.133 and 0.217 respectively (all P < 0. 05 ). In the group of elderly patients with hypertension and the elderly with hypertension and diabetes patients, there were no significant difference for the MT and TT genotype (P >0.05) , but there was significant difference for T allele frequency (P < 0.05). Conclusion The AGT gene and the TT genotype are resk factors of elderly hypertensive incidency, but not of diabetes.
NETL
NSTL
维普
万方数据
