Objective To investigate the role of urinary micro-albumin (mAlb) and serum cystatin C (CysC) in early diagnosis of pregnancy induced hypertension in patients with renal injury. Methods The urea nitrogen and creatinine concentration in serum were determined by enzymes-based method, while CysC concentration in serum was measured by an enhanced turbidimetric method. The mAlb in urine was performed by immune scattering method as well. These data were analyzed by correlation analysis. Results The results of mAlb in the pregnancy-induced hypertension, mild pre-eclampsia and severe pre-eclampsia groups were significantly higher (P <0.05) than those in the health control group. The serum CysC, urea nitrogen and creatinine in the severe group were significantly higher (P <0.05) than those in the control group. However, there was no significant correlations (P >0.05) between the other two groups and the control group. Moreover, with the aggravation of pregnancy-induced hypertension, the positive rate of urinary albumin increased rapidly and sensitively than other three indicators. Conclusion Urine mAlb is the most sensitive indicator in early diagnosis of kidney damage in patients with pregnancy-induced hypertension, while serum CysC is an endogenous indicator which is more specific for early diagnosis of severe pre-eclampsia pregnants.
NETL
NSTL
维普
万方数据
