急性冠状动脉综合征相关microRNA靶向通路及其功能分析
Acute coronary syndrome associated microRNA targeted pathways and their functions
林建宇 1朱雨捷 2王晶 2汤溢飞 2徐中华3
作者信息
- 1. 浙江省象山县红十字台胞医院心血管内科,浙江象山315731
- 2. 苏州大学系统生物学研究中心,江苏苏州,215006
- 3. 苏州大学附属第二人民医院胸心外科,江苏苏州215004
- 折叠
摘要
目的 利用生物信息学方法探讨急性冠状动脉综合征(ACS)中microRNA的功能,在通路层次上、系统地研究急性冠状动脉综合征的机理,寻找新的急性冠状动脉综合征相关的反应通路.方法 通过收集文献中报道的急性冠状动脉综合征相关的microRNA,利用计算方法预测这些microRNA的作用靶点,再将这些靶点在通路数据库中进行富集统计分析,对富集的通路进一步进行功能注解.结果 通过计算分析寻找到了microRNA靶向的7个新的可能的急性冠状动脉综合征相关的反应通路,供进一步实验验证.结论 急性冠状动脉综合征是一个复杂疾病,尽管不同的microRNA功能和作用机制不同,在通路层次上我们可以系统地注解它们的功能和作用.
Abstract
Objective To apply bioinformatics in the understanding of the molecular mechanisms of acute coronary syndrome (ACS) and to identify ACS associated pathways and to study the functions of mi-croRNAs in the developing of ACS. Methods First we collected the ACS associated microRNAs from PubMed databases, and then we applied bioinformatics for the prediction of microRNA targets, the predicted targets were mapped to pathways in GeneGO database for enrichment analysis. Results We identified seven novel putative ACS associated pathways, which deserve further experimental verification. Conclusion ACS is a complex disease and the functions of different microRNAs may be diverse and we could understand their functions in the pathway level.
关键词
急性冠状动脉综合征/microRNA/microRNA靶点预测/反应通路富集分析Key words
acute coronary syndrome/MicroRNA/MicroRNA target prediction/pathway enrichment analysis引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据