Objective To study the expression of CD40 and associated molecules human papilloma virus (HPV) , vascular endothelial growth factor ( VEGF) and CD34 on different types of malignant cervical cancer, and to study the effect of CD40 on the angiogenesis of cervical cancer. Methods Surgical biopsy specimens were obtained from 239 patients ( cervical squamous epithelium cancer 56 cases, cervical intraepithelial neoplasia 102 cases, chronic cervical inflammation 43 cases and the normal control 38). The expression of CD40 and associated molecules HPV, VEGF and CDJ4 microvessel density (MVD) on different types of malignant cervical cancers were examined by SP. The relation of CD40 and associated molecules and clinical significance were analyzed. Results There were significant differences between expression of CD40, HPV, VEGF and CD34 + MVD on cervical cancer and on the normal controls ( P < 0.05). There were a positive correlation between CD40 expression and HPV, VEGF CD34 + MVD( P < 0. 01 or < 0. 05 ). Furthermore, There was a close correlation between the expression of CD40 and lymph nodule metastasis and the invasive extent of muscular layer(P <0. 01 or <0. 05) in cervical cancer. Conclusion CD40 may be involved in neovascularization of cervical carcinoma, and CD40 and VEGF may be useful biomarkers for evaluating the risk of developing cervical carcinoma, and may also be used as a target for therapy.
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