维生素D3对2型糖尿病患者炎症因子水平的影响
Effects of vitamin D3 supplementation on inflammation in patients with type 2 diabetes mellitus
李晓岚 1李冰燕2
作者信息
- 1. 新疆医科大学第五附属医院内分泌科,新疆乌鲁木齐830011
- 2. 苏州大学医学部公共卫生学院卫生毒理学系,江苏苏州215123
- 折叠
摘要
目的 探讨维生素D3对2型糖尿病(T2DM)患者糖代谢和体内相关炎症因子水平的影响.方法 选择无急性并发症的T2DM患者85例.按性别、年龄因素随机分为基础治疗组(对照组)和基础治疗加维生素D3组(维生素D组).对照组采用基础药物将空腹血糖(FPG)控制在7.0 mmol/L以下,将餐后2h血糖(2 hPG)控制在10.0 mmol/L以下.维生素D组在对照组基础上口服维生素D31 000 IU/d.疗程12周.在疗程结束后的次日取空腹血清,ELISA法测定血清中炎症因子白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平.同时测定FPG、2hPG、超敏C反应蛋白(hs-CRP)和糖化血红蛋白(HbA1c).结果 经过12周的治疗,维生素D组患者的FPG、2 hPG和HbA1c值与对照组比较,差异均无统计学意义(均P＞0.05)；但维生素D组患者体内的hs-CRP、TNF-α和IL-6水平均明显低于对照组(均P ＜0.05).结论 维生素D3降低了T2DM患者体内的炎症状态.
Abstract
Objective To explore effects of vitamin D3 supplementation on inflammation in patients with type 2 diabetes mellitus (T2DM). Methods In according with selected criteria, 85 patients with T2DM were randomly divided into the control and vitamin D groups. Patients of both groups were treated with basic medicine to control the blood glucose level and the patients in vitamin D group were orally administered vitamin D3 1 000 IU daily in addition. High-sensitivity C-reactive protein (hs-CRP) , tumor necrosis factor-oc (TNF-a) , interleukin-6 (IL-6) , fasting plasma glucose (FPG) , 2 h-postprandial plasma glucose (2 hPG), and hemoglobin A1c (HbA1c) were assessed after the 12-week intervention. Results There was no significant difference in the level of FPG,2 hPG and HbAlc between two groups after treatment(all P>0.05). However, the level of TNF-α,IL-6 and hs-CRP in the vitamin D group was significantly lower than that in the control group (all P <0.05). Conclusion Vitamin D supplementation for 12 weeks has improved inflammation significantly in T2DM.
关键词
维生素D/2型糖尿病/炎性因子Key words
vitamin D/type 2 diabetes mellitus/inflammatory biomarker引用本文复制引用
基金项目
国家自然科学基金(81072286)
江苏省自然科学基金资助项目(SBK201221995)
出版年
2012
NETL
NSTL
万方数据