2型糖尿病患者血糖波动与踝肱指数的相关性
The correlation between glycemic variability and ankle-brachial index in type 2 diabetes mellitus patients
李慧娟 1鲁燕 1陆轶群 1樊华英1
作者信息
- 1. 苏州大学附属第一医院内分泌科,江苏苏州,215006
- 折叠
摘要
目的 研究2型糖尿病(T2DM)患者血糖波动与踝肱指数(ABI)的相关性.方法 根据ABI值将162例T2DM患者分为3组:A组44例,ABI≤0.9；B组103例,0.9 ＜ABI≤1.3;C组15例,ABI＞ 1.3.所有患者均采用动态血糖监测系统连续监测72 h血糖,计算平均血糖水平(MBG)及标准差(SD)、日内平均血糖波动幅度(MAGE)、变异系数(CV),并记录一般临床资料.结果 与B组比较,A、C组患者的年龄、病程、低密度脂蛋白-胆固醇(LDL-C)、糖化血红蛋白(HbA1c)的差异均有统计学意义(均P＜0.05)；A组的MBG、SD、MAGE和CV值均明显高于B组(均P＜0.05)；ABI与年龄、病程、HbA1c、MAGE、SD均成负相关(均P＜0.05),Logistic回归分析示患者年龄、病程、MAGE是ABI的独立影响因素.结论 血糖波动是ABI的危险因素,有可能增加糖尿病下肢动脉病变风险,需重视动态血糖监测.
Abstract
Objective To investigate relation between glycemic variability and ankle-brachial index ( ABI) in type 2 diabetes mellitus (T2DM) patients. Methods According to ABI, 162 patients were divided into three groups; group A with low ABI (ABI=S0. 9) , group B with normal ABI (0. 9 < ABI≤ 1.3), group C with high ABI ( ABI > 1. 3). All patients underwent continuous glucose monitoring system (CGMS) measurement for 72 h, then the mean blood glucose ( MBG) level and standard deviation ( SD) , mean amplitude of glucose excursions (MAGE) and coefficient of variation ( CV) were calculated. Clinical parameters were also recorded. Results Compared with group B, patients in group A and group C showed older age, longer course of diabetes, higher level of LDL-C and HbA1c (all P <0. 05). The value of MBG, SD, MAGE and CV in group A were higher than those in group B ( all P <0. 05 ) . A-nalysis showed ABI was negatively correlated with age, course, HbAlc, MAGE and SD (all P <0. 05). Logistic regression analysis revealed that age, course and MAGE were independent risk factors for low ABI (all P <0. 05). Conclusion Glycemic variability was the risk factor of lower ABI and CGMS which must be carefully monitored.
关键词
血糖波动/动态血糖监测系统/踝肱指数Key words
glycemic variability/continuous glucose monitoring system/ankle-brachial index引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据