心肌梗死患者血清HIF-1α、VEGF的表达与心肌缺血显像的相关性
Expressions of serum HIF-1α and VEGF and the correlation between the expression and the myocardial ischemia imaging
贺永明 1章斌 2杨向军 1吴翼伟2
作者信息
- 1. 苏州大学附属第一医院心内科,江苏苏州215006
- 2. 苏州大学附属第一医院核医学科,江苏苏州215006
- 折叠
摘要
目的 采用单光子发射型计算机断层(SPECT)显像技术研究缺血存活心肌与缺氧诱导因子-1((HIF-1α)和血管内皮生长因子(VEGF)变化的相关性.方法 201Tl再分布显像判断心肌梗死患者缺血存活心肌的多寡；再以ELISA法检测患者HIF-1α和VEGF水平,并分析201Tl显像检测缺血存活心肌与HIF-1α和VEGF的相关性.结果 SPECT显像检测获得的缺血存活心肌总积分与血清HIF-1α、VEGF水平变化显著相关(均P＜0.001).结论 缺血存活心肌节段总积分与HIF-1α、VEGF相关,检测血清HIF、VEGF可为指导冠心病介入治疗提供一个简单而实用的方法.
Abstract
Objective To study the correlation between the viable myocardia detected by SPECT technique and serum hypoxia inducible factor-1α(HIF-1α) , vascular endothelial growth factor(VEGF) . Methods Ischemic/viable myocardia after myocardial infarction was detected with the thallium-201 redistribution imaging; HIF-1α and VEGF levels were measured with ELISA. The correlation was analyzed. Results A significant correlation was revealed between the global score of ischemic/viable myocardia obtained from SPECT imaging and the changes of HIF-1α and VEGF(all P < 0. 001). Conclusion The correlation between the global score and the changes of HIF-la and VEGF may provide a simple, practi-cle and alternative method for interventional therapy in patients with coronay artey diseases.
关键词
单光子发射型计算机断层/乏氧诱导因子-1α/血管内皮生长因子/心肌梗死/相关性Key words
SPECT/HIF-1α/VEGF/myocardial infarction/correlation引用本文复制引用
基金项目
江苏省第4期"333高层次人才培养工程"资助项目(2011Ⅲ-2663)
苏州市科技计划项目(YJS0910)
出版年
2012
NETL
NSTL
维普
万方数据