Objective To evaluate the effect and safety of novel defibrillation electrode of P-700 series. Methods Cardiac catheter was used to induce and build ventricular fibrillation model on three different weight groups of Tai-hu pigs, according to the available energy in "The 2010 AHA Guidelines for CPR and ECC" , with P-500 series electrodes as control, Electrodes of P-700 and P-500 were utilized to do external defibrillate and resuscitation in vitro separately. The rate of successful defibrillation were recorded and Doppler ultrasound measurement were applied to evaluate the animals' myocardial function before and after defibrillation, Gross anatomy and pathological examination were performed after experiments. Results There was no obvious significance difference between the control groups and experimental groups on the rate of successful defibrillation(P >0. 05). Among the three groups, there was no obvious significance difference prior to and after experiment on left ventricular ejection fraction, fraction area change and left ventricular end-systolic thickness (all P > 0. 05 ). No obvious abnormal appearance was found in gross anatomy and pathological examination. Conclusion The efficacy and safety of P-700 series electrodes meet the standard.
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