蒙古族人群炎症标志物与血管紧张素Ⅱ和肾素活性的关系
Relationship between biomarkers of infammation and angiotensin Ⅱ and plasma renin activity among Mongolians
韦晓淋 1陆洪敏 2赵丽 3刘海英 4王珂 1卜晓青 1汤玲燕 1张永红1
作者信息
- 1. 苏州大学医学部公共卫生学院流行病与卫生统计学系,江苏苏州215123
- 2. 内蒙古通辽市医院手术室,内蒙古通辽028000
- 3. 内蒙古通辽市疾病预防控制中心慢病科,内蒙古通辽028000
- 4. 内蒙古通辽市科尔沁区第一人民医院神经内科,内蒙古通辽028000
- 折叠
摘要
目的 探讨蒙古族人群炎症标志物与血管紧张素Ⅱ(AngⅡ)和血浆肾素活性(PRA)的关系.方法 对2 589名蒙古族研究对象进行人口统计学等资料的收集、血压等的测量,以及C-反应蛋白(CRP)、可溶性E选择素(sE-selectin)、可溶性细胞间黏附分子-1(sICAM-1)以及AngⅡ和PRA的检测,用Logistic回归模型分析各炎症标志物水平与AngⅡ和PRA异常的关系.结果 PRA异常组的sE-selectin显著高于PRA正常组(18.9 ng/ml vs 17.5ng/ml,P＜O.001)；与sE-selectin的最低分位数水平组比较,第4分位数水平组PRA异常的多因素调整比值比(0R)值(95％CI)为1.42(1.08～1.87).AngⅡ异常组的CRP(6.3 mg/L vs 5.5 mg/L)和sICAM-1(335.3 ng/ml vs314.4 ng/ml)均显著高于正常组(P＜0.001)；与CRP的最低分位水平组比较,第4分位数水平组对AngⅡ异常的多因素调整OR值(95％CI)为1.94(1.44～2.60)；与sICAM-1的最低分位者比较,第4分位者对AngⅡ异常的多因素调整OR值(95％ CI)为1.44(1.11 ～1.87).结论 CRP和sICAM-1水平升高与AngⅡ异常相关联,sE-selectin 水平升高与PRA异常相关联.
Abstract
Objective To explore the relationship between biomarkers of infammation and angioten-sin Ⅱ (Ang Ⅱ ) and plasma renin activity ( PRA) among Mongolians. Methods The data on demographics etc. were collected, blood pressures were measured and C-reactive protein(CRP) , soluble E-se-lectin(sE-selectin) , soluble intercellular adhesion molecule 1 ( sICAM-1) , Ang Ⅱ and PRA were examined for 2 589 Mongolian. Logistic regression was used to analyze the association between the biomarkers and abnormal Ang Ⅱ and PRA among Mongolian. Results The average levels of sE-selectin was signif-cantly higher in the participants with abnormal PRA than those with normal PRA (18.9 vs 17. 5 ng/ml, P <0. 001). Compared with the lowest quartile of sE-selectin, the multivariable-adjusted odds ratio (95% confident interval) of abnormal PRA for the highest quartile was 1.42 (1.08 ~ 1. 87 ). The average levels of both CRP (6.3 vs 5.5 mg/L) and sICAM-1 (335.3 vs 314.4 ng/ml) were signifcantly higher in the participants with abnormal Ang Ⅱ than those with normal Ang Ⅱ. Compared with the lowest quartile of CRP, the multivariable-adjusted odds ratio (95% confident interval) of abnormal Ang Ⅱ for the highest quartile was 1.94(1.44 ~ 2.60); compared with the lowest quartile of sICAM-1, the multivariable-adjusted odds ratio (95% confident interval) of abnormal Ang Ⅱ for the highest quartile was 1.44(1. 11 ~ 1.87). Conclusion The levels of sE-selectin is associated with abnormal PRA, and the levels of CRP and sICAM-1 are associated with abnormal Ang Ⅱ.
关键词
炎症标志物/血管紧张素Ⅱ/血浆肾素活性Key words
biomarkers of infammation/angiotensin Ⅱ/plasma renin activity引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据