2型糖尿病患者血清缺氧诱导因子-1α与颈动脉粥样斑块的相关性
Relationship between serum hypoxia-inducible factor-1α and carotid plaque in patients with type 2 diabetes mellitus
鄂维琴 1施毕旻1
作者信息
- 1. 苏州大学附属第一医院内分泌科,江苏苏州215006
- 折叠
摘要
目的 观察2型糖尿病(T2DM)患者血清缺氧诱导因子-1α(HIF-1α)的变化,探讨其与动脉粥样硬化性大血管病变的关系.方法 选择32例T2DM合并颈动脉斑块患者(T2DM+ CP组),24例单纯T2DM患者(T2DM组),24名健康体检者(正常对照组),采用酶联免疫吸附法(ELISA法)测定血清HIF-1α浓度.结果 T2DM+ CP组和T2DM组HIF-1α水平均显著高于正常对照组(均P＜0.01),T2DM+ CP组HIF-1α水平明显高于T2DM组(P＜0.05).血清HIF-1α水平与空腹血糖、糖化血红蛋白C(HbA1c)、胰岛素抵抗指数(HOMA-IR)成明显正相关(均P＜0.05).多元线性逐步回归分析表明,HbA1c是血清HIF-1 α水平的独立影响因素.结论 T2DM患者体内高水平的血清HIF-1α与血糖、胰岛素抵抗有关,在大血管并发症的发生发展过程中起着重要的作用.
Abstract
Objective To observe the changes of type 2 diabetes mellitus(T2DM) patients' serum hypoxia inducible factor-1α (HIF-1α) ,and evaluate the relationship between serum HIF-1α and vascular lesions of atherosclerosis. Methods The serum level of HIF-1α in 32 T2DM with carotid plaques(T2DM + CP group), 24 T2DM without macrovascular complications(T2DM group) , and 24 controls was studied with ELISA method. Results The serum HIF-1α level in T2DM with and without carotid plaque group was significantly higher than that in the controls ( all P < 0. 01). Furthermore, among T2DM, the level of HIF-1 α. was higher in patients with carotid plaque than that without carotid plaque (P < 0. 05 ) . The serum HIF-1α was positively correlated with fasting plasma glucose, HbA1c and HOMA-IR (all P <0. 05). Multiple linear stepwise regression analysis showed that HbAlc was the independent determinants of HIF-1α. Conclusion High level of serum HIF-1α in T2DM patients concerns with blood glucose and insulin resistance , which plays an important role in the development of macrovascular complications.
关键词
2型糖尿病/缺氧诱导因子-1α/颈动脉粥样斑块Key words
type 2 diabetes mellitus/hypoxia-inducible factor-1α/carotid plaque引用本文复制引用
基金项目
苏州市科技发展计划(应用基础研究)项目(SYS201022)
出版年
2012
NETL
NSTL
维普
万方数据