Objective To explore the relationship between plasm 3-nitrotyrosine (3-NT) levels and Alzheimer disease( AD). Methods The subjects were 48 patients with AD and 78 controls ,including 41 patients with vascular dementia (VD) and the 37 normal controls ( NC ). Cognitive function and plasm 3-NT levels in three groups were tested by Mini mental state examination ( MMSE) and enzyme linked immunosorbent assay(ELJSA) Respectively. Results The levels of plasm 3-NT were ( 119.46 ±21. 82) nmol/L in AD patients, (70. 42 ± 11. 45) nmol/L in VD, and (55. 09 ± 9. 63) nmol/L in NC, respectively (all P < 0.05). The correlation analysis revealed that the plasm 3-NT levels were negatively correlated with the total MMSE scores (r= -0. 638, P< 0.05). Multivariable linear regression showed that the plasm 3-NT levels were also negatively correlated with the memory scores,the orientation scores , the attention scores and the calculation in the AD groups(all P <0.05). Conclusion 3-NT may be used as the biochemical indicator for observing AD,and may be used for differentiating AD and VD.
Alzheimer diseasevascular dementia3-nitrotyrosineMini mental state examination
NETL
NSTL
维普
万方数据
