Objective To investigate the expression of matrix metalloproteinase MMP9 in the pancreatic ductal adenocacinoma(PDAC) and its clinical significance. Methods Immunohistochemistry staining was performed to examine expressions of MMP9 in 11 normal pancreatic tissues and 88 specimens of the pancreatic adenocarcinoma. Results Immunohistochemistry staining revealed expression of MMP9 protein was significantly higher than that in the normal pancreatic tissues(P <0. 01). The expression of MMP9 was positivly correlated with TNM stage and lymph node metastasis ( P < 0. 01 ) , negativly correlated with survival time (P < 0. 01 ) , but there was no evident difference in tumor location and pathologic grade (P >0.05). Analytic results of COX regression showed that the expression of MMP9 was positivly correlated with prognosis of pancreatic carcinoma (P < 0. 01). Conclusion MMP9 plays an important role in the pathogenesis, development and metastasis of pancreatic cancer. Examining MMP9 is useful for assessing the prognosis for PDAC during therapy.
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NSTL
维普
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