Research progress of genes and omics related to decreased ovarian reserve
Decreased ovarian reserve(DOR)is one of the common causes of female infertility.Due to follicular atresia and ovulation,with the increase of age,some patients have a decrease in the number of follicles that can be recruited in ovary and a decrease in the ability to fertilize,accompanied by a decline in oocyte quality and an increased risk of spontaneous abortion.The programmed death of ovarian granulosa cells may lead to the final atresia of most follicles in DOR ovaries.However,the specific mechanism of DOR female fertility deficiency is not clear.Therefore,analyzing the pathogenesis of DOR has important guiding significance for the treatment and prevention of DOR.In recent years,some progress has been made in the study of DOR genomics,metabonomics and proteomics.Studies have shown that gene mutations,changes in lipid small molecules and protein molecules are all related to the occurrence of DOR.This paper reviews the research progress of DOR in genomics,metabonomics and proteomics in recent years,in order to provide new ideas for early diagnosis,intervention and treatment of DOR patients.
国家科技期刊平台
NSTL
万方数据
维普
