卵巢储备功能减退相关基因及组学研究进展
Research progress of genes and omics related to decreased ovarian reserve
周立飞 1郑琳璐 2李林青 1王文艺 3李建磊 3张萍萍 4孙艳美 4李亚丽4
作者信息
- 1. 河北省人民医院生殖遗传科,石家庄 050000;华北理工大学研究生学院,唐山 063210
- 2. 河北省人民医院生殖遗传科,石家庄 050000;河北北方学院研究生学院,张家口 075000
- 3. 河北省人民医院生殖遗传科,石家庄 050000;河北医科大学研究生学院,石家庄 050000
- 4. 河北省人民医院生殖遗传科,石家庄 050000
- 折叠
摘要
卵巢储备功能减退(DOR)是引起女性不孕症的常见原因之一.由于卵泡闭锁和排卵,随着年龄的增长,部分患者出现卵巢可募集的卵泡数目减少和受精能力减弱,以及同时伴有卵母细胞质量的下降和自然流产风险增高的现象.卵巢颗粒细胞(GCs)的程序性死亡可能导致了 DOR卵巢中的大多数卵泡的最终闭锁,但是DOR女性生殖力低下的具体机制尚不明确,因此解析DOR的发病机制对于DOR的治疗和预防有着重要的指导意义.近年来对于DOR基因组学、代谢组学和蛋白质组学的研究取得了一定的进展,研究显示基因突变、脂类小分子和蛋白质分子的变化均与DOR的发生有关.本文就近年来在DOR基因组学、代谢组学和蛋白质组学中的研究进展作一综述,以期为早期诊断、干预和治疗DOR患者提供新思路.
Abstract
Decreased ovarian reserve(DOR)is one of the common causes of female infertility.Due to follicular atresia and ovulation,with the increase of age,some patients have a decrease in the number of follicles that can be recruited in ovary and a decrease in the ability to fertilize,accompanied by a decline in oocyte quality and an increased risk of spontaneous abortion.The programmed death of ovarian granulosa cells may lead to the final atresia of most follicles in DOR ovaries.However,the specific mechanism of DOR female fertility deficiency is not clear.Therefore,analyzing the pathogenesis of DOR has important guiding significance for the treatment and prevention of DOR.In recent years,some progress has been made in the study of DOR genomics,metabonomics and proteomics.Studies have shown that gene mutations,changes in lipid small molecules and protein molecules are all related to the occurrence of DOR.This paper reviews the research progress of DOR in genomics,metabonomics and proteomics in recent years,in order to provide new ideas for early diagnosis,intervention and treatment of DOR patients.
关键词
卵巢储备功能减退/基因组学/非编码RNA/代谢组学/蛋白质组学Key words
Diminished ovarian reserve/Genomics/Non-coding RNA/Metabonomics/Proteomics引用本文复制引用
基金项目
河北省医学适用技术跟踪项目(GZ2021079)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据