Research progress of premature ovarian insufficiency based on metabolomics
Premature ovarian insufficiency(POI)is a reproductive endocrine disease characterized by sex hormone disorder and follicle depletion,resulting in infertility and perimenopausal syndrome.The etiology of POI is highly heterogeneous,with most causes remaining unknown.Metabolomics offers high-throughput characterization of metabolites in cells,tissues,and body fluids through advanced chemical analysis techniques.As downstream products of molecular regulation,metabolites can directly reveal the functions of upstream genes and proteins,as well as reflect changes in biological phenotypes.POI is closely associated with endocrine and metabolic disorders,making it crucial to investigate the metabolic profile of POI in order to understand its pathogenesis.This paper summarizes the application and research progress of metabolomics in POI from the perspectives of metabolomics overview,metabolic characteristics,metabolic markers,and metabolic pathways,in order to explore the diagnostic biomarkers and pathogenesis of POI from a metabolic perspective,providing new insights for clinical diagnosis and treatment.
国家科技期刊平台
NSTL
万方数据
维普
