首页|微生物感染在慢性子宫内膜炎致生殖障碍中的机制进展

微生物感染在慢性子宫内膜炎致生殖障碍中的机制进展

扫码查看
慢性子宫内膜炎(CE)主要是由宫腔致病微生物感染引发的子宫内膜慢性炎性疾病,与女性生殖障碍密切相关,但其具体机制尚不明了。近年研究认为,CE影响女性生殖预后的主要原因不仅在于宫腔微生物的存在,更重要的是微生物群与内膜微生态之间的相互作用,且与宫腔内菌群失调、代谢活动改变、内膜免疫炎症失调及基因异常表达等有关。本文围绕微生物群在CE发生、发展过程中的作用机制及其对女性生殖健康的影响等方面的研究进展进行综述,有助于为临床优化治疗方案并改善生殖预后提供科学依据。
Research progress on mechanism of reproductive disorders caused by microbial infections in chronic endometritis
Chronic endometritis(CE)is mainly a chronic inflammatory disease of the endometrium caused by pathogenic microorganisms in the uterine cavity,which is closely related to female reproductive disorders,but its specific mechanism is not yet clear.In recent years,studies have suggested that the main reason why chronic endometritis affects female reproductive outcomes is not only the presence of uterine microorganisms,but also the interaction between the microbial community and the endometrial microecology,which is related to uterine dysbiosis,metabolic changes,endometrial immune inflammation disorders,and abnormal gene expression.This paper reviews the research progress on the mechanism of microbiota in the occurrence and development of CE,as well as its impact on female reproductive health.It helps to provide scientific basis for optimizing treatment plans and improving reproductive prognosis in clinical practice.

Chronic endometritisPathogenic microorganismsReproductive disorders

王静怡、袁莹、邹志玲、陈雪梅

展开 >

广东医科大学,湛江 524001

东莞市松山湖中心医院,东莞 523326

慢性子宫内膜炎 病原微生物 生殖障碍

东莞市社会科技发展(重点)项目

201950715024177

2024

生殖医学杂志
北京协和医院 国家人口计生委科学技术研究所

生殖医学杂志

CSTPCD
影响因子:1.24
ISSN:1004-3845
年,卷(期):2024.33(1)
  • 47