微生物感染在慢性子宫内膜炎致生殖障碍中的机制进展
Research progress on mechanism of reproductive disorders caused by microbial infections in chronic endometritis
王静怡 1袁莹 1邹志玲 2陈雪梅1
作者信息
- 1. 广东医科大学,湛江 524001;东莞市松山湖中心医院,东莞 523326
- 2. 东莞市松山湖中心医院,东莞 523326
- 折叠
摘要
慢性子宫内膜炎(CE)主要是由宫腔致病微生物感染引发的子宫内膜慢性炎性疾病,与女性生殖障碍密切相关,但其具体机制尚不明了.近年研究认为,CE影响女性生殖预后的主要原因不仅在于宫腔微生物的存在,更重要的是微生物群与内膜微生态之间的相互作用,且与宫腔内菌群失调、代谢活动改变、内膜免疫炎症失调及基因异常表达等有关.本文围绕微生物群在CE发生、发展过程中的作用机制及其对女性生殖健康的影响等方面的研究进展进行综述,有助于为临床优化治疗方案并改善生殖预后提供科学依据.
Abstract
Chronic endometritis(CE)is mainly a chronic inflammatory disease of the endometrium caused by pathogenic microorganisms in the uterine cavity,which is closely related to female reproductive disorders,but its specific mechanism is not yet clear.In recent years,studies have suggested that the main reason why chronic endometritis affects female reproductive outcomes is not only the presence of uterine microorganisms,but also the interaction between the microbial community and the endometrial microecology,which is related to uterine dysbiosis,metabolic changes,endometrial immune inflammation disorders,and abnormal gene expression.This paper reviews the research progress on the mechanism of microbiota in the occurrence and development of CE,as well as its impact on female reproductive health.It helps to provide scientific basis for optimizing treatment plans and improving reproductive prognosis in clinical practice.
关键词
慢性子宫内膜炎/病原微生物/生殖障碍Key words
Chronic endometritis/Pathogenic microorganisms/Reproductive disorders引用本文复制引用
基金项目
东莞市社会科技发展(重点)项目(201950715024177)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据