A retrospective analysis of neonatal outcomes resulting from IVF/ICSI-ET with donor sperm
Objective:To explore neonatal outcomes resulting from in vitro fertilization/intracytoplasmic sperm injection and embryo transfer(IVF/ICSI-ET)with donor sperm and husband's sperm.Methods:A retrospective analysis was conducted with clinical data from 6 926 newborns and their mothers who underwent IVF/ICSI-ET treatment at Reproductive Medicine Center of the Third Affiliated Hospital of Guangxi Medical University from April 2011 to April 2021.The participants were divided into two groups based on different sperm sources:husband sperm group(n=6 153)and donor sperm group(n=773).General information and assisted reproduction data of infertile women in the two groups were compared.The newborn outcomes of singleton and twin births,as well as the outcomes of newborns born through different assisted reproduction methods(IVF/ICSI),were also compared.Results:There were 6 153 neonates in the husband sperm group and 773 neonates in the donor sperm group.There was no significant difference in the average age between the two groups(P＞0.05).The mean infertility years[(5.99±3.66)years vs.(4.57±3.13)years],the proportion of primary infertility women(61.19％vs.40.32％),the proportion of fertilization mode of IVF assisted pregnancy(95.34％vs.83.16％),the rate of high-quality embryos transferred(96.63％vs.95.22％)and the proportion of twin births(47.09％vs.42.16％)in the donor sperm group were significantly higher than those of the husband sperm group(P＜0.05),while the mothers'BMI[(21.15±2.69)kg/m2]was significantly lower when compared with the husband sperm group[(21.57±2.82)kg/m2,P＜0.05].There were no significant differences in the mean number of transplanted embryos and newborn sex ratio between the two groups(P＞0.05).The number of births(single or twin)and the method of pregnancy assistance(IVF/ICSI)had no impact on gestational weeks,birth weight,cesarean section rate,premature birth rate,macrosomia birth rate,low birth weight rate and birth defect rate(P＞0.05).The most common types of birth defects in both groups were abnormalities in circulatory and genitourinary systems.Conclusions:IVF/ICSI-ET with donor sperm could not increase the risk of adverse neonatal outcomes.H owever,there is still a need to pay close attention to offspring safety and assess associated risks during future long-term follow-ups.
万方数据
维普
