Effects of chromosomal polymorphisms on the outcome of IVF/ICSI-ET
Objective:To investigate the impacts of chromosomal polymorphisms on pregnancy outcomes in infertile couples who undergo fresh embryo transfer after in vitro fertilization or intracytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET).Methods:Three hundred and eighty-two infertile couples who underwent the first IVF/ICSI-ET fertility treatment with fresh embryo transfer for infertility at the Department of Reproductive Medicine,Linyi Maternal & Child Health Hospital from January 2020 to January 2022 were retrospectively analyzed.The patients were divided into three groups:female polymorphism group(n=22),male polymorphism group(n=23),and the normal group(n=337).Results:Among 382 infertile couples,45 cases of chromosomal polymorphism were detected,with an incidence rate of 11.78％(45/382).There were no significant differences in terms of female age,male age,body mass index,infertility duration,concentrations of anti-Mullerian hormone(AMH),basal follicle-stimulating hormone level,the number of basal antral follicles,as well as the mode of fertilization,infertility factors,infertility type among the three groups(P＞0.05).There were no significant differences in ovulation regimen,total dose of gonadotropin used,endometrial thickness on the day of human chorionic gonadotropin(HCG),the number of oocytes retrieved,the number of M Ⅱ oocytes,the number of fertilized oocytes,the number of 2PN,and the number of top-quality embryos among the three groups(P＞0.05).All three groups of patients had similar embryo implantation rate,biochemical pregnancy rate,clinical pregnancy rate,miscarriage rate,preterm birth rate,and live birth rate in fresh embryo transfer cycles(P＞0.05).Conclusions:Chromosomal polymorphism has no significant impact on pregnancy outcomes in patients undergoing IVF/ICSI-ET.
万方数据
维普
