Relationship between high-frequency power in heart rate variability and pregnancy outcomes in patients with IVF/ICSI-ET
Objective:To explore the correlation between high frequency power(HF)in heart rate variability(HRV)and pregnancy outcomes of patients undergoing IVF-ET.Methods:Clinical data of 329 patients received IVF/ICSI-ET in Xingtai Infertility Specialist Hospital from January 2022 to June 2022 were analyzed retrospectively.According to the tertiles of HF levels,the patients were divided into three groups,group A(HF 7.91-197.06,n=110),group B(HF 198.22-358.03,n=109)and group C(HF 360.03-3 121.14,n=110).The results of psychological assessment results[self-rating anxiety scale(SAS)score,self-rating depression scale(SDS)score],endometrial condition,and pregnancy outcome were compared among the three groups.Spearman correlation was used to analyze the correlation between HF and SAS,SDS scores and pregnancy outcome indicators.Results:There was no difference in general information and basic endocrinology hormone level among the three groups.There was a significant difference in the SAS score among the three groups(P＜0.05).The SAS score of group C was significantly lower than that of group A(P＜ 0.05).There was no significant difference in the SDS score among the three groups(P＞0.05).In terms of endometrial receptivity,the pulsatility index(PI)of endometrial blood flow[(1.68±0.59)vs.(1.97±0.39),(1.88± 0.39)],the frequency of endometrial peristalsis[(1.76±0.93)vs.(2.68±1.58),(2.30±1.36)]in group C were significantly lower than those in group A and group B(all P＜0.05).In terms of embryonic outcomes,the fertilization rate of group C was significantly higher than that of group A and group B(66.59％vs.60.03％,63.03％,P＜0.05),and implantation rate(54.49％vs.40.96％)was significantly higher than that of groups A(P＜0.05).The correlation analysis results showed that HF was negatively correlated with SAS score and peristaltic wave frequency(P＜0.01),and positively correlated with implantation rate(P＜0.05).Conclusions:HF in HRV may reflect the body's good ability to regulate psychological stress.A higher HF may indicate better endometrial receptivity and implantation rate.Medical personnel should attach importance to the detection of HRV,intervene in a timely manner,and appropriately increase their HF level.
Autonomic nervous systemHigh frequency power(HF)Endometrial receptivityPregnancy outcome
万方数据
维普
