Research progress on metabolomics of follicular fluid in patients with polycystic ovary syndrome
Polycystic ovary syndrome(PCOS)is a complex and heterogeneous endocrine disorder that affects 5％-18％of women of reproductive age,while the etiology and pathophysiology of PCOS are still not completely understood.PCOS is the most common cause of anovulatory infertility and PCOS patients are prone to develop ovarian hyperstimulation syndrome,low fertilization rates,and high abortion rates during in vitro fertilization-embryo transfer(IVF-ET).Follicular fluid metabolites provide nutrients for oocytes at all stages,and changes in small molecule metabolites will seriously affect the growth of oocytes and the developmental potential of embryos.This article reviews the metabolites in follicular fluid of patients with PCOS,in order to provide evidences for exploring the pathogenesis of low oocyte developmental potential in patients with PCOS and finding more effective drug targets.
Polycystic ovary syndromeFollicular fluidMetabolomicsIn vitro fertilization-embryo transfer
万方数据
维普
