The effect of combined application of endometrial receptivity and pre-implantation genetic testing in frozen embryo transfer of patients with repeated implantation failure
Objective:The aim of this study was to assess the effects of combined application of endometrial receptivity testing(ERT)and pre-implantation genetic testing(PGT)in patients with repeated implantation failure(RIF)in frozen embryo transfer(FET).Methods:The patients with RIF in FET were recruited in Center for Reproductive Medicine of Xuzhou Maternity and Child Health Care Hospital between January 2018 and January 2023.The patients were divided into four groups according to different evaluation methods:138 with ERT and PGT(the combined group),324 without ERT or PGT(the RIF group),147 only with ERT(the ERT group),and 121 only with PGT(the PGT group).The basic characteristics and the FET outcome were compared among the four groups.Multivariate logistic regression analysis was used to analyze the independent factors affecting live birth rate of FET.Results:The endometrial receptivity period of most RIF patients was delayed by 1 to 2 days in the combined group and the embryo transfer time was adjusted according to the evaluation result of ERT.The FET results showed that embryo implantation rate(EIR),intrauterine pregnancy rate(IPR)and live birth rate(LBR)in the combined group were significantly higher than those of the PGT group,the ERT group as well as the RIF group(P＜0.05).Multivariate logistic regression analysis showed that PGT,ERT,high-quality blastocyst transplantation and female age were the independent factors influencing live birth rate.Conclusions:The combined application of ERT and PGT could improve FET outcomes of RIF patients,which maybe better than the separate application of ERT or PGT.
万方数据
维普
