Evaluation on simplified insulin release and glucose tolerance experiments among patients with polycystic ovary syndrome
Objective:To study the effect of simplified the insulin release and glucose tolerance experiment from a time perspective on evaluating insulin resistance(IR)and abnormal glucose metabolism in polycystic ovary syndrome(PCOS).Methods:Through the retrospective study,320 PCOS patients who had completed insulin release and glucose tolerance experiments(clinical golden standard)from August 2021 to August 2022 were selected.It was assumed that the patients only received Fast plasma glucose(FPG)and fasting insulin(FINS)test or fasting and 2-hour post glucose load blood glucose and insulin test.The sensitivity and consistency with gold standard of the two simplified method were evaluated.Results:The prevalent rate of IR or abnormality of glucose metabolism was 80.0％(256/320).And it was 97.5％(115/118)and 69.8％(141/202)among overweight and non overweight PCOS patients respectively.In detection of IR or abnormal glucose metabolism,the sensitivity of the two methods was 93.0％and 96.5％(κ=0.585)respectively among overweight patients.Whereas the sensitivity of the two methods was 58.2％and 74.5％respectively among non overweight patients.In detection of abnormal glucose metabolism,the sensitivity of the two methods was 16.7％and 100％(κ=1.000)respectively among overweight patients.Conclusions:Test of IR and abnormal glucose metabolism should be administered on all PCOS patients.For overweight PCOS patients,fasting and 2-hour post glucose load blood glucose and insulin can replace insulin release and glucose tolerance test.But for non-overweight PCOS patients,both of the two simplified methods have the risk of misdiagnose.
Polycystic ovary syndromeInsulin resistanceInsulin release testGlucose tolerance test
万方数据
维普
