Study on regression of cervical intraepithelial neoplasia grade 2 in women under 25 years old
Objective:To determine the regression of cervical intraepithelial neoplasia grade 2(CIN2)among women under 25 years old after 24 months of treatment.Methods:A total of 540 CIN2 patients who were screened and confirmed in the outpatient department of Nantong Cancer Hospital from January 2015 to December 2020 were selected as the research subjects.The included patients underwent the colposcopy examination at least once every 6 months and cooperated with biopsy,lasting for 24 months.According to the regression of CIN2 lesions in patients within 24 months,the included patients were divided into a regression group(273 cases)and a non-regression group(267 cases).Single-level factor analysis was conducted on the baseline data of the two groups,and a multivariate logistic analysis was used to explore the influencing factors of non-regression of CIN2 lesions.The predictive value of each factor/indicator was evaluated using receiver operating characteristic curve(ROC)and paired chi-square test.Results:At the end of 24 months of follow-up,50.56％of CIN2 patients experienced regression of the lesion.The results of univariate and multivariate analyses showed that CIN2 and CIN2+of the colposcopy impression,human papillomavirus(HPV)16 infection,highly squamous intraepithelial lesions by cytological examination,and smoking were risk factors for non-regression of lesions in C1N2 patients under 25 years old(P＜0.05),while the early diagnosis was a protective factor(P＜0.05).The predictive value of HPV16 combined with colposcopy and cytological examinations for non-regression of CIN2 patients'lesions was high,with an area under the ROC curve(AUC)of 0.822 and a 95％CI of(0.677,0.962).Conclusions:The CIN2 lesions in more than half of patients under the age of 25 may automatically subside within 24 months without traumatic treatment.The combination of HPV16,colposcopy,and cytological examination results has a good predictive value for the non-regression of CIN2 lesions,and is worthy of close attention by clinical doctors.
万方数据
维普
