Research progress on the occurrence and development of intestinal flora and polycystic ovary syndrome
Polycystic ovary syndrome(PCOS)is an endocrine and metabolic disorder with complex etiology,the main clinical manifestations of which are oligoovulation,amenorrhea,and even infertility,often accompanied by hirsutism and acne,and is closely related to obesity,insulin resistance(IR)and depression,seriously affecting the health of women of childbearing age.Intestinal microbiome disorders are believed to be likely to mediate the occurrence and the development of PCOS through inflammation and oxidative stress.Adjusting the intestinal microecological environment through supplementation of probiotics(including synbiotics)and fecal transplantation(FMT)can actively alleviate the clinical symptoms of hyperandrogenemia(HA),glucose and lipid metabolism and central immune abnormalities in PCOS patients,providing a new idea for the treatment of PCOS.This review mainly focuses on the mediation role of intestinal flora on PCOS in the pathogenesis,the improvement of clinical symptoms,and its potential application.
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