Brain derived neurotrophic factor(BDNF)and neurotrophin-5(NT-5),which act on the same receptors-TrkB and p75NTR,are members of neurotrophin family and a kind of secretory polypeptides which are secreted by the target tissue innervated by nerves.BDNF and NT-5 are widely expressed in the ovary and play important roles in multiple reproductive physiological activities,such as follicular assembly and development,oocyte maturation,ovulation and steroidogenesis in granulosa and theca cells.Infertility is a reproductive disorder caused by multiple etiology.Among infertile patients,there is an abnormal secretion of BDNF and NT-5 in the ovary.Therefore,understanding the research progress of BDNF and NT-5 in female reproductive endocrine system may provide new directions for the treatment of infertility and new indicators for predicting pregnancy outcomes of assisted reproduction.
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