脑源性神经营养因子和神经营养因子-5在女性生殖内分泌领域的研究进展
Research progress of brain derived neurotrophic factor and neurotrophin 5 in female reproductive endocrine system
娄艳茹 1刘晨虹 2严杰 3杨蕊4
作者信息
- 1. 北京大学第三医院妇产科生殖医学中心,女性生育力促进全国重点实验室
- 2. 国家妇产疾病临床医学研究中心
- 3. 辅助生殖教育部重点实验室
- 4. 北京市生殖内分泌与辅助生殖技术重点实验室,北京 100191
- 折叠
摘要
脑源性神经营养因子(BDNF)和神经营养因子-5(NT-5)属于神经营养因子家族,是一类由神经支配的靶组织分泌的分泌型多肽,两者通过作用于相同的受体发挥作用.BDNF和NT-5在卵巢表达广泛,发挥着促进卵泡组装和发育、卵母细胞成熟、排卵、调节颗粒细胞和膜细胞类固醇激素分泌等多种生理作用.不孕症是由多种病因导致的一种生育障碍状态,不孕症患者卵巢局部的BDNF和NT-5存在异常分泌情况.因此,了解BDNF和NT-5在女性生殖内分泌领域的研究进展,可能为不孕症治疗提供新方向,为辅助生殖结局的预测提供新指标.
Abstract
Brain derived neurotrophic factor(BDNF)and neurotrophin-5(NT-5),which act on the same receptors-TrkB and p75NTR,are members of neurotrophin family and a kind of secretory polypeptides which are secreted by the target tissue innervated by nerves.BDNF and NT-5 are widely expressed in the ovary and play important roles in multiple reproductive physiological activities,such as follicular assembly and development,oocyte maturation,ovulation and steroidogenesis in granulosa and theca cells.Infertility is a reproductive disorder caused by multiple etiology.Among infertile patients,there is an abnormal secretion of BDNF and NT-5 in the ovary.Therefore,understanding the research progress of BDNF and NT-5 in female reproductive endocrine system may provide new directions for the treatment of infertility and new indicators for predicting pregnancy outcomes of assisted reproduction.
关键词
脑源性神经营养因子/神经营养因子-5/酪氨酸激酶受体B/不孕症Key words
Brain derived neurotrophic factor/Neurotrophin-5/Tyrosine kinase receptor B/Infertility引用本文复制引用
基金项目
国家自然科学基金(82171632)
国家自然科学基金(T2293764)
国家重点研发计划(2021YFC2700605)
国家重点研发计划(2022YFC2703000)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据