摘要
早发性卵巢功能不全(POI)是女性40岁之前出现的卵巢功能衰退或丧失,严重影响女性身心健康和生育功能,目前临床尚无法提供治愈方法.间充质干细胞(MSCs)来源广泛,具有再生、增殖及修复受损组织的本领,在POI治疗领域具有广阔应用前景.但MSCs的推广应用仍面临难题,如进入体内后存活率低、旁分泌及分化能力受损、活细胞包装及运输的局限性、临床应用存在致瘤或诱发免疫反应等.因此,探索不同形式的MSCs优化策略以解决上述难题成为当前研究热点.本文总结了当前MSCs治疗POI的研究进展,综述了近年来MSCs治疗POI的优化策略,以期进一步为POI的治疗提供参考依据.
Abstract
Primary Ovarian Insufficiency(POI)is the decline or loss of ovarian function that occurs before the age of 40,which seriously affects woman's physical and mental health as well as their reproductive function.And clinically,there is no known cure.Mesenchymal stem cells(MSCs),which come from a wide range of sources and have the ability to regenerate,proliferate and repair damaged tissues,have a broad prospect in POI treatment.However,the application of MSCs still faces difficulties,such as low survival rate in vivo,impaired paracrine and differentiation abilities,limitations in packaging and transportation of living cells,and tumorigenic or immune-induced reactions in clinical applications.Therefore,it has become a hot research topic to explore strategies for the optimization of MSCs treatments.In this paper,we summarize the current research progress of MSCs for POI,and review the optimization strategies for MSCs-based treatment of POI in recent years,with a view to further providing a reference basis for the treatment of POI.
维普
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