Comparing live birth rate and cumulative live birth rate of long-acting long protocol in the early follicular and mid-luteal phases
Objective:To compare the live birth rate per transplant cycle and cumulative live birth rate per oocyte retrieval cycle of controlled ovary hyperstimulation using long-acting long protocol in the early follicular and mid-luteal phases in order to explore the advantages and disadvantages of two kinds of pituitary down-regulation protocols.Methods:A retrospective analysis of the patients(a total of 1 969 cycles)with normal ovarian reserve function who underwent IVF-ET in Reproductive Center of Ningbo University Affiliated Women and Children's Hospital from January 2018 to December 2021.According to different ovulation protocols,these patients were grouped into early follicular group(receiving long-acting long protocol in early follicular phase,461 cycles)and luteal phase group(receiving long-acting long protocol in the mid-luteal phase,1 508 cycles).Basic characteristics and clinical outcomes of the two groups were compared.Results:There were no significant differences in basic characteristics of the two controlled ovarian stimulation protocol,such as age,infertility years,body mass index(BMI),anti-Müllerian hormone(AMH)level,and the cause of infertility(P＞0.05).The average gonadotropin(Gn)day of the early follicular group was higher than those of the luteal phase group[(11.0±3.3)days vs.(10.6±3.1)days,P＜0.01)].The average Gn doses in the early follicular group were lower than those of the luteal phase group[(2 390.9±331.3)U vs.(2 645.5±308.1)U,P＜0.01)].There were no significant differences in average number of dominant follicles,the numbers of eggs retrieved and available embryos between the two groups(P＞0.05).The average levels of estradiol(E2),LH and progesterone in the peripheral blood of the early follicular group were significantly lower than those in the luteal phase group(P＜0.01).There were no significant differences in endometrial thickness on the day of transplantation and the number of transplant embryos between the two groups(P＞0.05).The live birth rate in fresh transplant cycle of the early follicular group was lower than that of the luteal phase group,showing no significant difference(44.81％ vs.49.34％,P=0.26).In the early follicular group,both the incidence of moderate or severe OHSS and cumulative live birth rate were lower than those of the luteal phase group,showing no significant differences(0.87％ vs.1.59％,68.11％ vs 70.76％,P＞0.05).Conclusions:The clinical outcome of long-acting long protocol in the early follicular phase is similar to that in mid-luteal phase in patients with normal ovarian reserve function.
Controlled ovarian hyperstimulationIVF-ETLive birth rateCumulative live birth rate
国家科技期刊平台
NSTL
万方数据
维普
