Effects of failed ovulation induction on reproductive outcomes in frozen-thawed embryo transfer
Objective:To investigate the association between ovulation induction(OI)failure and the outcomes of frozen-thawed embryo transfers(FET)in oligo-ovulation and non-ovulation women,and to explore the risk factors of OI failure.Methods:This retrospective study included women who attempted their first FET at Northwest Women's &Children's Hospital between January 2018 and March 2022.A total of 478 patients were included in this study,of which 277(57.95％)were in the OI success group and 201(42.05％)were in the OI failure group according to the outcomes of OI.The primary outcomes were clinical pregnancy rate and live birth rate.Logistic analysis was utilized to find out the risk factors of OI failure.Results:The clinical pregnancy rate(62.45％vs.59.70％)and the live birth rate(53.43％vs.51.74％)of the two groups were similar(P＞0.05).The basal LH levels in the OI failure group were significantly higher than those in the OI success group(P=0.03).After adjusting the variables,it was found that baseline LH level was an independent risk factor of OI failure[OR=1.079,95％CI(1.020,1.141),P=0.008].Conclusions:There were no effects of OI failure before FET on pregnancy outcomes in oligo-ovulation and non-ovulation women,and the basal LH level was an independent risk factor of OI failure.
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