Influence of serum anti-Müllerian hormone levels on clinical outcomes of IVF/ICSI in patients of different ages
Objective:To explore the effects of low serum anti-Müllerian hormone(AMH)level(≤1.1 ng/ml)on embryo quality,clinical pregnancy rate,miscarriage rate,and embryo villus chromosomal aneuploidy in miscarriage patients,as well as the live birth rate among women of different age groups.Methods:A retrospective analysis was conducted on the data of patients who underwent IVF/ICSI at the Reproductive Medicine Center of the Second People's Hospital of Guangdong Province from January 2015 to December 2022.A total of 20 886 cycles of oocyte retrieval,17 218 cycles of embryo transfer and 124 cycles of embryo villus chromosomal examination in miscarriage patients after embryo transfer were evaluated.Based on their AMH values,the patients were divided into a study group(AMH ≤1.1 ng/ml)and a control group(AMH＞1.1 ng/ml).Patients in each group were subdivided according to their ages into five subgroups with ages of not more than 30 years,31-35 years,36-38 years,39-40 years and more than 40 years.A comparison was made in terms of embryo quality,pregnancy rate,live birth rate,miscarriage rate,and the status of chromosomal examination of embryo chorionic villi in miscarriage patients between two groups and among five subgroups.Results:The rates of normal fertilization,D3 high-quality embryos,D3 available embryos and blastocyst formation,clinical pregnancy and live birth in the study group were significantly lower than those in the control groups regardless of their ages(P＜0.05).In the study group,the rate of miscarriage showed a trend of increasing with age,but a significant higher rate was found only in those aged over 40 years(P＜0.05).The chromosomal anomalies of abortive fetal tissues were detected in all 14 patients aged over 40 years.Conclusions:AMH and age jointly influence embryo quality and pregnancy outcomes in patients treated with assisted reproductive technology.
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