Study on the relationship between serum CD26,CD109 and clinicopathological features and prognosis in patients with high-grade serous ovarian cancer
Objective:To investigate the relationship between serum cluster differentiation 26(CD26),serum cluster differentiation 109(CD109)and clinicopathological features and prognosis in patients with high-grade serous ovarian cancer(HGSOC).Methods:A total of 145 HGSOC patients admitted to Suqian First Hopital and Taixing People's Hospital from July 2019 to July 2020 were selected as the HGSOC group,and 100 normal healthy women who underwent physical examinations in the same hospital during the same period were selected as the control group.Enzyme linked immunosorbent assay was used to measure the serum levels of CD26 and CD109 in two groups and compare them.The relationship between CD26 and CD109 levels and clinical pathological characteristics of HGSOC patients was analyzed,and Cox regression model was used to analyze the factors of the prognosis of HGSOC patients.Kaplan-Meier survival curves were drawn to analyze the 3-year overall survival rate of patients with high and low levels of serum CD26 and CD109.Results:Compared with the control group,the levels of serum CD26 and CD109 in HGSOC group were significantly increased(P＜0.05).There were no significant differences in serum CD26 and CD109 levels among patients with different ages and tumor diameters,with or without ascites and preoperative CA125 levels(P＞0.05).The levels of serum CD26 and CD109 in patients with lymph node metastasis and FIGO stage Ⅲ+Ⅳ HGSOC were significantly higher than those in patients without lymph node metastasis and FIGO stage Ⅰ+Ⅱ HGSOC(P＜0.05).The Kaplan-Meier survival curve showed that the 3-year overall survival rate in CD26 high-level group[59.72％(43/72)]was significantly lower than that in CD26 low-level group[79.10％(53/67),P＜0.05].The 3-year overall survival rate in CD109 high-level group[62.50％(50/80)]was significantly lower than that in CD109 low-level group[77.97％(46/59),P＜0.05].Cox regression model analysis showed that lymph node metastasis,FIGO stage Ⅲ+Ⅳ,high serum CD26 level and high serum CD109 level were risk factors for poor prognosis of HGSOC(P＜0.05).Conclusions:Serum CD26 and CD109 are highly expressed in HGSOC patients,and their elevated expression levels are related to distant metastasis,FIGO stage Ⅲ+Ⅳ and poor prognosis.
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