Research progress on the role of DNA methylation in epigenetic modification of endometriosis
Endometriosis is one of the common diseases among women of childbearing age.More and more evidence suggests that epigenetic abnormalities play an important role in the pathogenesis of endometriosis.Among them,DNA methylation is one of the most studied epigenetic regulatory mechanisms.DNA methylation links the observed changes in gene expression in endometriosis with hormones and environmental factors,which may be one of the mechanisms underlying the occurrence of endometriosis.This article reviews the research progress on genes related to estrogen and progesterone synthesis,estrogen and progesterone receptor,homologous box genes,TET protein genes,abnormal methylation of matrix metalloproteinase 2 genes,whole genome methylation analysis,and targeted drug therapy of endometriosis.Although these studies have found a correlation between DNA methylation and changes in the gene expression,whether these molecular changes represent the cause or consequence of this disease remains an unanswered question.These findings will provide a basis for the pathogenesis and targeted drug therapy research of endometriosis.Due to the need for long-term repeated drug treatment for EMs,the safety of such drugs is a key issue for future research.
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