DNA甲基化在子宫内膜异位症表观遗传修饰作用中的研究进展
Research progress on the role of DNA methylation in epigenetic modification of endometriosis
代会颖 1李晶 1李越 1刘慧娟 1王倩 1周彩霞1
作者信息
- 1. 徐州市第一人民医院,徐州 221000
- 折叠
摘要
子宫内膜异位症(EMs)是育龄期妇女常见的疾病之一.越来越多的证据表明,表观遗传异常在EMs的发病机制中起着重要作用.其中,DNA甲基化是研究最多的表观遗传调控机制之一.DNA甲基化将EMs中观察到的基因表达改变与激素和环境因素联系了起来,这可能是EMs发生的机制之一.本文对EMs中雌孕激素合成相关基因、雌孕激素受体相关基因、同源盒基因、TET蛋白基因、基质金属蛋白酶2基因甲基化异常、全基因组甲基化分析以及EMs的药物靶向治疗的研究进展进行了综述.虽然这些研究发现了 DNA甲基化与基因表达改变有相关性,但这些分子变化是代表疾病的原因还是疾病的后果,仍然是一个有待回答的问题.这些发现将为EMs的发病机制和药物靶向治疗提供依据.由于EMs需要长期反复药物治疗,该类药物的安全性是未来研究的重点问题.
Abstract
Endometriosis is one of the common diseases among women of childbearing age.More and more evidence suggests that epigenetic abnormalities play an important role in the pathogenesis of endometriosis.Among them,DNA methylation is one of the most studied epigenetic regulatory mechanisms.DNA methylation links the observed changes in gene expression in endometriosis with hormones and environmental factors,which may be one of the mechanisms underlying the occurrence of endometriosis.This article reviews the research progress on genes related to estrogen and progesterone synthesis,estrogen and progesterone receptor,homologous box genes,TET protein genes,abnormal methylation of matrix metalloproteinase 2 genes,whole genome methylation analysis,and targeted drug therapy of endometriosis.Although these studies have found a correlation between DNA methylation and changes in the gene expression,whether these molecular changes represent the cause or consequence of this disease remains an unanswered question.These findings will provide a basis for the pathogenesis and targeted drug therapy research of endometriosis.Due to the need for long-term repeated drug treatment for EMs,the safety of such drugs is a key issue for future research.
关键词
子宫内膜异位症/表观遗传/DNA甲基化Key words
Endometriosis/Epigenetics/DNA methylation引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据