Comparison of clinical outcomes of different doses of progesterone in progestin-primed ovarian stimulation protocol for patients with poor ovarian response
Objective:To compare the clinical outcomes of 20 mg and 30 mg of dydrogesterone in the progestin-primed ovarian stimulation(PPOS)protocol for patients with poor ovarian response(POR).Methods:A retrospective study on clinical outcomes of 114 treatment cycles was conducted in 114 patients who underwent IVF/ICSI-ET in Reproductive Medical Center,Strategic Support Force Medical Center between January 2017 and December 2022.According to the dose of dydrogesterone,they were divided into 20 mg of dydrogesterone group with 20 cycles and 30 mg of dydrogesterone group with 94 cycles.The basic characteristics,ovulation induction,embryo transfer,and clinical outcomes were evaluated.Results:There were no significant differences in basic characteristics,body mass index,duration of infertility between the two groups(P＞0.05).Moreover,there were no significant differences in the dose of gonadotropin(Gn),the duration of Gn use,the number of oocyte retrieved,the number of M Ⅱ oocyte,LH level on the trigger day,the number of available embryos between the two groups(P＞0.05).There was no significant difference in the clinical pregnancy rate,live birth rate,and miscarriage rate between the two groups of frozen thawed embryo transfer(FET)cycles(P＞0.05).Conclusions:For POR patients,similar clinical outcomes were obtained with 20 mg of dydrogesterone and 30 mg of dydrogesterone in the PPOS protocol.Dydrogesterone 20 mg orally can significantly reduce the drug dosage and save the cost of drug,which is worthy of clinical attention.However,the sample size of this study is relatively small,and further exploration is needed after expanding the sample size and improving the research design.
万方数据
维普
