The effect of hyperbaric oxygen therapy on pregnancy outcomes in infertile patients with poor ovarian response treated with IVF/ICSI-ET
Objective:To explore the influence of hyperbaric oxygen therapy(HBOT)on pregnancy outcomes in infertile patients with poor ovarian response(POR)treated with IVF/ICSI-ET.Methods:A retrospective analysis of clinical data(86 cycles)of infertile patients who underwent IVF/ICSI-ET treatment for POR at the Reproductive Medicine Center of Changhai Hospital Affiliated to Naval Medical University from February 2019 to June 2023 was conducted.Based on the use of HBOT as an adjuvant therapy,they were divided into a study group(HBOT combined with ovulation induction therapy,n=43)and a control group(only ovulation induction therapy,n=43).The basic characteristics,ovarian function related indicators before and after intervention,ovulation induction status,and pregnancy outcomes of the two groups were compared,and the ovulation induction and embryo development of the previous treatment cycle and the current cycle were compared between the study group and the control group.Results:There were no significant differences in basic characteristics such as age,body mass index(BMI),and infertility factors between the two groups(P＞0.05).There were no significant differences in FSH level,E2 level,FSH/LH,and basal antral follicle count(AFC)between the study group and the control group before and after intervention(P＞0.05).However,the FSH level in the study group after HBOT combined with ovulation induction treatment were significantly lower than those in the control group after ovulation induction[(9.51±1.69)U/L vs.(11.75±4.44)U/L,P＜0.001].In the study group,there were no significant differences in the number of retrieved oocytes,MⅡ oocytes,cleavage,and fertilization between the previous and current cycles(P＞0.05),but the number of embryos obtained in the current cycle and the number of high-quality embryos were significantly higher than those of the previous cycle[(1.91±0.94)vs.(1.30±0.67)and(1.83±1.01)vs.(0.98±0.66),P＜0.05].There were no significant differences in various parameters between the previous cycle and the current cycle in the control group(P＞0.05).The number of embryos obtained in the study group[(1.91±0.94)vs.(1.51±0.80)]and the number of high-quality embryos[(1.83±1.01)vs.(1.28±0.66)]were significantly higher than those in the control group in the current cycle(P＜0.05).The clinical pregnancy rate of the study group showed an increasing trend compared to the control group(32.6％vs.22.4％),showing no significant difference(P＞0.05).There were no adverse reactions in the study group after HBOT treatment.Conclusions:The use of HBOT as an adjuvant therapy for IVF/ICSI-ET in POR patients may be beneficial in increasing the number of embryos obtained and high-quality embryos,and the clinical pregnancy rate also shows an upward trend without significant adverse reactions.
万方数据
维普
