Study on clinical signs and glycolipid metabolism of PCOS women with different body mass indices
Objective:To explore the endocrine hormone levels,glycolipid metabolism parameters and clinical features of PCOS patients with different body mass indices(BMI),and to investigate the correlation of anti-Müllerian hormone(AMH)levels and BMI.Methods:A total of 167 PCOS patients diagnosed and treated in Yangzhou Maternal and Child Care Service Center from January 2020 to October 2022 were recruited.The patients were divided into three groups based on their BMI:normal group(18.5 kg/m2＜BMI＜24.0 kg/m2,n=14),the overweight group(24.0 kg/m2≤BMI＜28.0 kg/m2,n=25)and the obesity group(BMI≥28.0 kg/m2,n=128).Basic characteristics,endocrine hormone levels,glucose and lipid metabolism parameters and clinical manifestations were compared among the three groups.Pearson correlation analysis was used to analyze the relationship between BMI and endocrine hormone levels,glucose and lipid metabolism parameters.The relationship between AMH and polycystic changes in the ovaries was analyzed.Results:The hip circumference(HC),waist circumference(WC)and waist to hip ratio(WHR)in the obesity group were significantly higher than those of the normal group(P＜0.05).The serum levels of LH/FSH,LH,AMH and sex hormone-binding globulin(SHBG)in the obesity group were significantly lower than those in the normal group(P＜0.05).The serum levels of total cholesterol(TC),low-density lipoprotein(LDL)and fasting blood glucose(FPG)in obesity group were significantly higher than those of other two groups(P＜0.05).The serum levels of high-density lipoprotein(HDL)and 25-OH-D3 in the normal group were significantly higher than those in other two groups,while the serum levels of triglycerides(TG),uric acid(UA),fasting insulin(FINS)and homeostasis model assessment of insulin resistance(HOMA-IR)were significantly lower(P＜0.05).The incidence of clinical manifestations of acanthosis nigricans,impaired glucose tolerance and metabolic syndrome was significantly higher in the obesity group than those in other two groups(P＜0.05).Pearson correlation analysis showed significant correlations between BMI and the levels of AMH,FPG,FINS,HOMA-IR,TG,TC,HDL and LDL(P＜0.05).The AMH level had a significantly negative correlation with 25-OH-D3 level in PCOS patients(r=-0.245,P=0.005).The level of AMH in patients with polycystic ovarian changes was significantly higher than that in patients without polycystic ovarian changes[(6.78±2.74)ng/ml vs.(5.68±2.37)ng/ml,P＜0.05].Conclusions:PCOS patients in the obesity group were more likely to have endocrine disorders and abnormal glucose and lipid metabolism.The higher the BMI,the more severe the endocrine disorders,which was prone to metabolic syndrome.The higher the AMH,the more severe polycystic ovarian changes for PCOS patients.
Polycystic ovary syndromeBody mass indexAnti-Müllerian hormoneCarbohydrate metabolismLipid metabolism
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维普
