Application of laparoscopic nerve-sparing radical hysterectomy in patients with stage Ⅰa and Ⅰb1 cervical cancer
Objective:To explore the effects of laparoscopic nerve-sparing radical hysterectomy(LNSRH)on urinary fluidity,sexual function and complications in patients with stage Ⅰa and Ⅰb1 cervical cancer.Methods:A total of 80 patients with early-stage cervical cancer admitted to Xuzhou Maternal &Child Health Hospital Department of Gynecology from May 2019 to May 2022 were prospectively selected and included in the study.They were divided into the control group and the observation group by random number table method,with 40 cases in each group.The control group received laparoscopic radical hysterectomy(LRH),and the observation group underwent LNSRH.The basic characteristics,perioperative indicators,tumor marker levels,urodynamics indicators,sexual function scores and postoperative complications were compared between the two groups.Results:There were no significant differences in clinical stage,age,body mass index and pathological type between the two groups(P＞0.05).The operation time of observation group was significantly longer than that of control group[(246.85±30.79)min vs.(227.41±28.43)min,P＜0.05].There were no significant differences in the amount of blood loss,the number of lymph node dissection,the length of vaginal resection and the length of hospital stay between the two groups(P＞0.05).The levels of carbohydrate antigen 125(CA-125)and squamous cell carcinoma antigen(SCCA)were significantly lower after operation compared with those before operation(P＜0.05),but there was no significant difference between the two groups after operation(P＞0.05).After operation,the maximum urine flow rate(MFR),maximum detrusor pressure(MDP)and bladder compliance levels in two groups were significantly lower than those before operation,but these indicators of the observation group were significantly higher than those in the control group(P＜0.05).After operation,the scores of female sexual function scale(FSFI)for each dimension in both groups were significantly lower than those before operation,but these scores of the observation group were significantly higher than those of the control group(P＜0.05).Postoperative complications in the observation group were significantly less than those in the control group(12.50％vs.32.50％,P＜0.05).Conclusions:Both LNSRH and LRH are effective for patients with stage Ⅰa and Ⅰb1 cervical cancer,which could effectively reduce the levels of tumor markers.However,LNSRH has little effect on urodynamics and sexual function,and has fewer postoperative complications.
万方数据
维普
