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子宫内膜息肉发病机制研究进展

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子宫内膜息肉(EPs)是一种局部子宫内膜腺体和间质过度生长的子宫内膜良性病变,主要表现为异常子宫出血、不孕等,且EPs切除术后易复发,影响女性的生殖健康,因此明确EPs发病机制尤为重要。本文从遗传学因素、细胞增殖与凋亡失衡、激素失衡、炎性因子分泌异常以及免疫细胞比例失衡方面综述了 EPs的发病机制,以期为更深入的机制研究提供更多参考。
Research progress in the pathogenesis of endometrial polyps
Endometrial polyps(EPs)are benign endometrial lesions involving excessive growth of local endometrial glands and stroma,manifested mainly as abnormal uterine bleeding and infertility.EPs are prone to recurrence after resection,affecting women's reproductive health.For this reason,elucidating the pathogenesis of EPs is of particular importance.This article reviews the pathogenesis of EPs from the perspectives of genetic factors,imbalance between cell proliferation and apoptosis,hormonal imbalance,abnormal secretion of inflammatory factors,and imbalance in the proportion of immune cells,in order to provide a reference for more insights of mechanism research.

Endometrial polypsPathogenesisDiagnosisPrevention

蒯丹、唐清涛、李小燕、王颖梅、田文艳、张慧英

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天津医科大学总医院,天津 300052

天津市女性生殖健康与优生重点实验室,天津 300052

子宫内膜息肉 发病机制 诊断 预防

国家自然科学基金天津市医学重点学科(专科)建设项目天津市自然科学基金

82171629TJYXZDXK-031A23JCYBJC00720

2024

生殖医学杂志
北京协和医院 国家人口计生委科学技术研究所

生殖医学杂志

CSTPCD
影响因子:1.24
ISSN:1004-3845
年,卷(期):2024.33(8)