Effects of different embryo transfer strategies on pregnancy outcomes in patients following repeated frozen-thawed high-quality single blastocyst transfer
Objective:To explore the effect of different embryo transfer strategies on the outcome of pregnancy following repeated frozen-thawed high-quality single blastocyst transfer.Methods:A retrospective study was conducted on women undergoing repeated frozen-thawed high-quality single blastocyst transfer in Reproductive Medicine Center of Chenzhou First People's Hospital from July 2018 to October 2022.A total of 887 patients were included in the study and divided into two groups as group Ⅰ(age＜35,n=568)and group Ⅱ(age≥35,n=319).Moreover based on the embryo transfer strategy,patients were divided into group A(one high-quality blastocyst transfer group,n=79),group B(two high-quality blastocyst transfer group,n=79),group C(one high-quality blastocyst+one poor-quality blastocyst transfer group,n=117),group D(double poor-quality blastocyst transfer group,n=141)and group E(double high-quality cleavage transfer group,n=226).The basic clinical characteristics and pregnancy outcomes among the five groups were compared respectively.Results:In group Ⅰ,there were no significant differences in the age,basal FSH level,endometrial thickness on the transfer day among the five groups(P＞0.05),the clinical pregnancy rate(60.41％vs.77.08％,72.73％,69.74％,70.83％,P＜0.05)and live birth rate(49.80％vs.68.75％,61.82％,59.21％,61.11％,P＜0.05)in group A were significantly lower than those of other groups(P＜0.05),the multiple pregnancy rate in group E was significantly higher than that in group A(38.24％vs.1.35％,P＜0.05)while significantly lower than those in group B(67.57％,P＜0.05),group C(57.50％,P＜0.05)and group D(56.60％,P＜0.05).In group Ⅱ,there were no significant differences in the basic clinical characteristics,the clinical pregnancy rate and live birth rate among the five groups(P＞0.05),while the multiple pregnancy rate in group A was significantly lower than those of other four groups(0.00％vs.33.33％,29.17％,20.59％,15.00％,P＜0.05).Conclusions:For patients undergoing repeated frozen-thawed high-quality single blastocyst transfer,the choice of frozen-thawed embryo transfer strategy needs comprehensive evaluation.When patients aged not less than 35 years,the five embryo transfer strategies achieve similar clinical outcomes and have to be selected based on the actual situation.When patients aged less than 35 years,in the absence of conditions for frozen-thawed high-quality single blastocyst transfer,double high-quality cleavage embryo transfer would be the better policy,but its multiple-pregnancy risk is relatively high,which should be paid attention to.
Frozen-thawed embryo transferSingle blastocyst transferRepeated cycleEmbryo transfer strategy
万方数据
维普
