Application of different antagonists in GnRH antagonist regimens
Objective:To compare the clinical outcomes of IVF/ICSI-ET with injectable cetrorelix versus ganirelix acetate in a GnRH antagonist regimen.Methods:The clinical data of 340 cycles of IVF/ICSI-ET fertility treatment with the antagonist regimen in Chengdu Jinjiang District Maternal and Child Health Hospital from December 2022 to August 2023 were retrospectively analyzed.According to the use of antagonist drugs,the cycles were divided into the cetrorelix group(n=170)and the ganirelix group(n=170).The basic characteristics,the ovulation promotion and clinical pregnancy outcomes were compared between the cetrorelix group and the ganirelix group.Results:There were no significant differences in age,body mass index(BMI),basal levels of sex hormone between the two groups(P＞0.05).There were no significant differences in the number of Gn days,Gn dosage,sex hormone levels on HCG day,the number of retrieved oocytes,the number of M]]oocytes,total fertilization rate,the number of high-quality cleavage embryos,the number of blastocysts formed,the number of high-quality blastocysts,the incidence of moderate-severe OHSS,the rate of LH elevation(＞10 U/L)and the rate of less than 1 U/L of LH level on HCG day between the two groups(P＞0.05).The total cost of antagonist use was significantly lower in the cetrorelix group compared with the ganirelix group[RMB(1 383.49±495.71)vs.RMB(1 762.22±608.66),P＜0.05].There were no significant differences in HCG positive rate,clinical pregnancy rate,the implantation rate,multiple pregnancy rate,ectopic pregnancy rate,early miscarriage rate in the cetrorelix group with 61 cycles of fresh embryo transfer and the ganirelix group with 56 cycles of fresh embryo transfer(P＞0.05).Conclusions:Domestic cetrorelix and imported ganirelix in GnRH antagonist regimen had similar inhibition effect of early ovulation,with good clinical pregnancy outcomes in both groups.The cost of domestic cetrorelix was lower.A comprehensive evaluation can be conducted based on the specific situation and economic conditions of patients in clinical practice.
万方数据
维普
