Study on the relationship between thyroid autoimmunity and ovarian reserve function in euthyroid infertile women
Objective:To explore the relationship between thyroid autoimmunity(TAI)and ovarian reserve function in euthyroid infertile women.Methods:A retrospective analysis was conducted on the clinical data of 4 567 euthyroid infertile patients who underwent their first IVF/ICSI cycle in the Center of Reproductive Medicine of the Third Affiliated Hospital of Zhengzhou University from January 2021 to October 2023.The reference values for antithyroid antibodies(ATA)in our center are as follows:thyroid peroxidase antibody(TPOAb)level 34 IU/ml;thyroglobulin antibody level(TgAb)≤115 IU/ml.Patients who tested positive for TPOAb and/or TgAb were classified as ATA-positive group,while patients who tested negative for both TPOAb and TgAb were classified as ATA-negative group.Ovarian reserve function indicators were compared between the two groups and further stratified analysis were conducted using cut-off points including the age at 35 years old and thyroid stimulating hormone(TSH)at 2.5 mIU/L.Results:The age of patients was significantly higher in ATA-positive group than that of ATA-negative group(P＜0.05).The free triiodothyronine(FT3)level in ATA-positive group was significantly lower than that in ATA-negative group(P＜0.05).After adjusting for confounding factors such as age,the antral follicle count(AFC)showed significantly lower in the ATA-positive group when compared with the ATA-negative group(P＜0.05).In the subgroup with TSH＞2.5 mIU/L,the AFC was also significantly lower in ATA-positive group than that of ATA-negative group(P＜0.05).In the subgroup of patients aged 35-40 years,both the anti-Müllerian hormone(AMH)level and AFC were significantly lower in ATA-positive group than those in ATA-negative group(P＜0.05).Conclusions:TAI may be associated with diminished ovarian reserve in euthyroid infertile women,and this association may primarily exist in euthyroid infertile patients at advanced age and those with slightly elevated TSH levels.
Thyroid autoimmunityInfertilityOvarian reserve function
万方数据
维普
