Application of two different kinds of Cetrorelix in GnRH antagonist regiments in young infertile patients
Objective:To compare the clinical efficacy of two different formulations of cetrorelix,a GnRH antagonist(GnRH-ant),in young infertile patients undergoing IVF-ET cycles.Methods:A retrospective analysis was conducted on the clinical data of infertile patients under 35 years old who were treated with the GnRH-ant protocol at the Reproductive Medicine Department of Xuzhou Maternity and Child Health Care Hospital from March 2022 to June 2023.A total of 650 cycles were analyzed.The patients were divided into two groups based on the type of GnRH-ant used:the domestic cetrorelix group(domestic group,249 cycles)and the imported cetrorelix group(imported group,401 cycles).The basic characteristics,ovulation induction and embryo laboratory parameters,and clinical pregnancy outcomes were compared between the two groups.Results:There were no statistically significant differences in the patients'age,duration of infertility,body mass index(BMI),baseline hormone levels,and the level of anti-Müllerian hormone(AMH)between the two groups(P＞0.05).The domestic cetrorelix group showed significantly higher embryo yield,number of high-quality embryos on day 3,day 3 high-quality embryo rate as well as a higher number and rate of high-quality blastocyst when compared to the imported cetrorelix group(P＜0.05).There were also no significant differences in total dose of gonadotropins(Gn),the duration of Gn administration,levels of LH,estradiol(E2),and progesterone(P)on trigger day,the number of retrieved oocytes,the number of mature(MⅡ)oocytes,the number of 2 pronuclear(2PN)zygotes,the number of blastocyst formed,the proportion of elevated LH levels on trigger day,as well as incidence rates of moderate to severe OHSS and adverse reactions after injection between the two groups(P＞0.05).After 42 cycles with fresh embryo transfer in the domestic group and 73 in the imported group,there were no statistically significant differences in HCG positive rate,the implantation rate,clinical pregnancy rate,multiple pregnancy rate,early miscarriage rate,and live birth rate between the two groups(P＞0.05).Conclusions:When using the GnRH-ant protocol to induce ovulation in young patients,both domestic and imported cetrorelix can achieve similar ovulation suppression effects as well as good clinical pregnancy outcomes.Moreover,the use of domestic cetrorelix can utilize a higher number of available embryos and high-quality embryos.
万方数据
维普
