The effect of serum progesterone levels on HCG trigger day on the outcome of fresh embryo transfer in GnRH antagonist cycles
Objective:To analyze the effect of serum progesterone(P)levels on HCG trigger day on the outcome of fresh embryo transfer in GnRH antagonist cycles.Methods:Patients who underwent IVF/ICSI cycle with fresh embryo transfer in the Center for Reproductive Medicine,Renmin Hospital of Wuhan University from June 2020 to October 2023 were included in the analysis.A total of 658 cycles of ovulation promotion and fresh embryo transfer were performed using an antagonist protocol.All the included patients were divided into four groups based on serum P levels on HCG trigger day:group A(P＜2.23 nmol/L,n=235),group B(2.23 nmol/L≤P＜3.18 nmol/L,n=246),group C(3.18 nmol/L≤P＜4.13 nmol/L,n=151)and group D(4.13 nmol/L≤P≤6.36 nmol/L,n=26).The basic characteristics,clinical outcomes such as embryo implantation rate,clinical pregnancy rate and related pregnancy complications were compared among the four groups.Results:There were no statistically significant differences in basic characteristics except the age of women among the four groups(P＞0.05).The age of women showed an overall difference among the four groups(P＜0.05),but there were no significant differences when compared with each other(P＞0.05).The embryo implantation rate and the clinical pregnancy rate in group A were the highest(38.5％and 52.3％,respectively),and significantly higher than those of group D(16.0％and 23.1％,respectively,P＜0.05),while no significant differences were found among other groups(P＞0.05).And HCG positive rate,early miscarriage rate and ectopic pregnancy rate showed no significant differences among the four groups.Conclusions:In the GnRH antagonist regimen,the serum P level on HCG trigger day was closely related to pregnancy outcomes.For young women with normal ovarian reserve who received an antagonist protocol to promote ovulation,when P＜2.23 nmol/L,the embryo implantation rate and clinical pregnancy rate were the highest.When P＜4.13 nmol/L,fresh embryo transfer could be considered.When P≥4.13 nmol/L,it is recommended trying to freeze the whole embryo.
万方数据
维普
