Analysis of factors associated with spontaneous miscarriage after IVF-ET in infertile patients
Objective:To analyze the factors associated with spontaneous miscarriage after IVF-ET in infertility patients.Methods:A retrospective analysis was conducted on the clinical data of 357 infertile patients who received IVF-ET for the first time at Peking Union Medical College Hospital from July 2022 to June 2023.The patients were divided into the group without miscarriage(n=312)and the group with miscarriage(n=45)according to the occurrence of spontaneous miscarriage or not,and the clinical data of the two groups such as the general characteristics,male semen parameters,the present and history diseases,and IVF-ET related data were compared.Logistic regression model was employed to analyze the factors related to spontaneous miscarriage after IVF-ET in the infertility patients.Results:The results of Logistic regression model analysis found that not less than 35 years of age,＞24 kg/m2 of body mass index(BMI),male sperm viability of grade D,≤15X 106/ml of male sperm concentration,＞20％of male sperm DNA fragmentation index,history of more than three induced abortions,history of more than three spontaneous abortions,history of more than two uterine manipulations,history of uterine fibroids,and grade C embryos transferred were risk factors for spontaneous miscarriage after IVF-ET in infertile patients(OR＞1,P＜0.05).Conclusions:Advanced age,higher BMI,more induced/spontaneous abortions,more uterine operations,history of uterine fibroids,and poor quality of transferred embryos of an infertile patient and poor sperm viability,low sperm concentration,and a high index of DNA fragmentation of the sperm of her husband could increase the risk of spontaneous miscarriage after IVF-ET.
万方数据
维普
