首页|子宫内膜容受性的调节机制研究进展

子宫内膜容受性的调节机制研究进展

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子宫内膜容受性是母体子宫内膜对胚胎的接受能力,是决定胚胎能否顺利植入的关键因素。良好的子宫内膜容受性对于胚胎植入及成功妊娠至关重要,且对女性生育力的维持具有重要意义,但其复杂的生理过程涉及多种调节因素,具体分子机制尚未完全阐明。本文从免疫、激素、表观遗传及微生物调节等方面对子宫内膜容受性的调节机制进行综述,以期为临床诊疗提供指导,从而改善妊娠结局。
Research progress on the regulation mechanism of endometrial receptivity
Endometrial receptivity is the ability of the maternal endometrial to accept the embryo,which is the key factor to determine whether the embryo can be successfully implanted.Optimal endometrial receptivity is essential for embryo implantation and successful pregnancy,and is important for the maintenance of female fertility.However,its complex physiological process involves many regulatory factors,and the specific molecular mechanism has not been fully elucidated.The article reviews the regulatory mechanisms of endometrial receptivity from the aspects of immunity,hormones,epigenetic modifications and microbiota,in order to provide guidance for clinical diagnosis and treatment,so as to improve pregnancy outcomes.

Endometrial receptivityImmunityInflammationHormonesEpigenetic modificationsMicrobiota

周佳慧、杨贵芳、任杰、郭瑞霞、李小诺、杨晓丽

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山西医科大学第九临床医学院 太原市中心医院,太原 030009

子宫内膜容受性 免疫 炎症 激素 表观遗传 微生物

山西省回国留学人员科研资助项目太原市卫生健康委员会科研项目太原市科学技术局重点项目

2021-175Z2022002202202

2024

生殖医学杂志
北京协和医院 国家人口计生委科学技术研究所

生殖医学杂志

CSTPCD
影响因子:1.24
ISSN:1004-3845
年,卷(期):2024.33(10)