Effect of lipid profiles on pregnancy outcomes of patients with ovulatory disorders in frozen-thawed embryo transfer cycles
Objective:To investigate the impact of blood lipid levels on pregnancy outcomes in patients with ovulatory disorders during frozen-thawed embryo transfer(FET)cycles.Methods:Patients aged less than 38 years and suffering from ovulation disorders were recruited at the Genetic and Reproductive Center of Suzhou Municipal Hospital from January 2017 to May 2023.The patients underwent ART with antagonist regimen during follicular phase.Their first FET cycles were included in this study,459 totally.Based on serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)levels,the patients were categorized into two groups as a normal blood lipid group(212 cycles)and a dyslipidemia group(247 cycles).The demographic characteristics,laboratory parameters,and pregnancy outcomes between these two groups were compared for the first FET cycle,followed by multivariate logistic regression analysis for pregnancy outcomes.Results:The duration of infertility,body mass index(BMI),the levels of TG,TC and LDL-C,total gonadotropin(Gn)dosage,and days of Gn administration were significantly higher in the dyslipidemia group than those in the normal blood lipid group,while the HDL-C level was significantly lower than the latter(P＜0.05).There were no significant differences between the two groups in terms of the number of oocytes retrieved,fertilization method,normal fertilization rate(2PN rate),blastocyst formation rate,high-quality blastocyst rate,and the rate of transferable embryos(P＞0.05).Additionally,there were no significant differences in the proportion of cleaved embryos and blastocysts transferred,as well as endometrial thickness on the day of embryo transfer(ET)between the two groups(P＞0.05).The implantation rate(49.2％vs.58.5％)and live birth rate(44.1％vs.57.5％)were significantly lower in the dyslipidemia group compared to the normal blood lipid group(P＜0.05),whereas the early miscarriage rate was significantly higher in the dyslipidemia group(18.6％vs.10.1％,P＜0.05).Multivariate logistic regression analysis indicated that dyslipidemia was an independent factor for the miscarriage rate[OR=2.679,95％CI(1.304,5.503),P＜0.05]and live birth rate[OR=0.588,95％CI(0.398,0.868),P＜0.05].Conclusions:Dyslipidemia may adversely affect pregnancy outcomes in patients with ovulatory disorders undergoing FET cycles,leading to a reduction in live birth rates and an increase in miscarriage rates.
万方数据
维普
