Influencing of letrozole combined with HMG on pregnancy and perinatal outcomes in patients with unexplained infertility during artificial insemination by husband
Objective:To compare the effects of letrozole(LE)combined with HMG and LE alone on pregnancy and perinatal outcomes in patients with unexplained infertility during artificial insemination by husband(AIH),and to provide evidence for selecting the best strategy for ovulation induction.Methods:A retrospective study was conducted to analyze 340 cycles of 340 patients with unexplained infertility who underwent AIH for the first time at Department of Reproductive Medicine of Luoyang Maternal and Child Health Hospital from January 2016 to December 2022.Patients were divided into two groups as LE combined with HMG group(n=154)and LE alone group(n=186)according to the strategy of ovulation induction.Clinical characteristics and outcomes of ovulation induction were compared between the two groups.A multivariate logistic regression analysis was used to evaluate the impact factors of clinical pregnancy rate and live birth rate.Results:There were no significant differences in age,infertility years,antral follicle count,follicle diameter,endometrium thickness on HCG day and male sperm concentration in AIH between the two groups(P＞0.05),while there were significant differences in body mass index(BMI),the duration of ovulation induction and the number of ovulation between the two groups(P＜0.05).The clinical pregnancy rate(2 6.62％vs.16.67％)and live birth rate(24.03％vs.15.05％)in LE combined with HMG were significantly higher than those in LE group(P＜0.05),and there were no significant differences in perinatal outcomes such as gestational weeks,birth height and birth weight between the two groups(P＞0.05).The multivariate logistic analysis results showed that the number of ovulation was an independent factor of clinical pregnancy rate[OR=1.707,95％CI(1.089,2.676),P=0.020]and live birth rate[OR=1.666,95％CI(1.053,2.636),P=0.029].Conclusions:LE combined with HMG can improve the clinical pregnancy rate and live birth rate of patients with unexplained infertility in AIH cycles,which may be related to the increase of ovulation number,but it has no significant impact on perinatal outcomes.
万方数据
维普
