The effects of different intrauterine infusion treatments on pregnancy outcomes of patients with thin endometrium during frozen-thawed embryo transfer cycles
Objective:To compare the clinical outcomes of platelet-rich plasma(PRP)and Granulocyte colony-stimulating factor(G-CSF))in patients with thin endometrium undergoing frozen-thawed embryo transfer(FET).Methods:A retrospective analysis of 186 patients with thin endometrium undergoing IVF-FET in Reproductive Center of Beijing Amcare Beisanhuan Women & children's Hospital from January 1,2020 to June 30,2023 was conducted.Patients were divided into PRP group(105 cases)and G-CSF(81 cases)group according to different clinical intervention with intrauterine infusion.Comparisons were conducted on the changes of endometrial thickness before and after infusion,and pregnancy outcomes including clinical pregnancy rate,biochemical pregnancy rate,ongoing pregnancy rate,early miscarriage rate.Then the patients in each group were divided into two subgroups as severe thin endometrium group and mild thin endometrium group with endometrial thickness of 6.5 mm as the boundary.The changes of endometrial thickness before and after infusion as well as pregnancy outcomes were compared.Results:The average increase of endometrial thickness before and after infusion was 25.04％in PRP group and 18.32％in G-CSF group respectively with significant differences(P=0.003).No significant differences were found in pregnancy outcomes between the two groups(P＞0.05).In severe thin endometrium group,the increase of endometrial thickness in PRP group was significantly higher than that in G-CSF group(31.23％vs.22.34％,P=0.009)while there were no significant differences in pregnancy outcomes between the two groups(P＞0.05).In mild thin endometrium group,the increase of endometrial thickness in PRP group was still significantly higher than that in G-CSF group(19.52％vs.13.11％,P=0.033)and no significant differences were found in pregnancy outcomes(P＞0.05).Conclusions:Both PRP and G-CSF intrauterine infusion can effectively improve the pregnancy outcomes of FET cycles in patients with thin endometrium,with PRP showing better performance in increasing endometrial thickness,indicating that PRP intrauterine infusion is an effective treatment.
万方数据
维普
