首页|Antiparasitic and apoptotic modulatory activities of curcumin and extracts of Nigella sativa L,Zingiber officinale Rosc.,and Punica granatum L.in combination with spiramycin against chronic cerebral toxoplasmosis in immunocompromised mice

Antiparasitic and apoptotic modulatory activities of curcumin and extracts of Nigella sativa L,Zingiber officinale Rosc.,and Punica granatum L.in combination with spiramycin against chronic cerebral toxoplasmosis in immunocompromised mice

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  • 国家科技期刊平台
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Objective:To examine the effect of coadministration of different medicinal plant extracts(curcumin and extracts of Nigella sativa L.[N.sativa,Jia Hei Zhong Cao],Zingiber officinale Rosc.[Z officinale,Sheng Jiang],and Punica granatum L[P.granatum,Shi Liu])with spiramycin(SP)against the cystogenic ME-49 Toxoplasma gondii(T.gondii)strain in immunocompromised mice.Methods:We utilized 68 mice categorized into 8 groups:2 non-infected controls(immunocompetent and immunocompromised),1 infected control,and 5 infected and treated groups.Following the experiment,the cerebral tissues of each mouse underwent parasitological,histopathological,and immunohistochemical evaluations.Results:Compared with the infected non-treated group,all infected treated groups showed significant reductions in brain cyst numbers(all P＜.05),with the highest reduction rate(77.4％)recorded for P.granatum and SP combination(G8).Only G8 showed a significant reduction in mouse deaths compared with the other groups.With regards to restoring histopathological changes and decreasing inflammation,the groups infected and treated with curcumin and P.granatum combined with SP showed the best results(P＜.05).Combinations of curcumin and extracts of Z officinale and P.granatum with SP signif-icantly restored the cerebral expression of caspase-3 compared with the N.sativa extract combination(P＜.05).G8 showed non-significant expression compared with the local expression in the negative control groups.Conclusion:Our study revealed that the coadministration of P.granatum extract with SP was the most effective combination against chronic cerebral toxoplasmosis.

Medicinal plantsToxoplasma gondiiME-49Punica granatum LCerebral caspase-3

Mennat-Elrahman A.Fahmy、Amany A.Abdel-Aal、Soad I.Hassan、Maisa A.Shalaby、Manal Badawi、Marwa Esmat

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Medical Parasitology Department,Theodor Bilharz Research Institute(TBRI),Giza,12685,Egypt

Department of Medical Parasitology,Faculty of Medicine,Cairo University,Cairo,11562,Egypt

Department of Postgraduate Studies & Scientific Research,Armed Forces College of Medicine(AFCM),Cairo,11711,Egypt

Department of Pathology,National Research Centre,Giza,12622,Egypt

Department of Medical Parasitology,Faculty of Medicine,Misr University for Science and Technology,6th of October City,Giza,12585,Egypt

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2024

10.1016/j.jtcms.2024.06.007

中医科学杂志(英文)
北京中医药大学,清华大学出版社有限公司

中医科学杂志(英文)

ISSN：2095-7548
年,卷(期)：2024.11(4)