Objective:To explore the risk factors of gangrenous cholecystitis,and to provide evidence-based medical evidence for early diagnosis and improvement of prognosis.Methods:Database of Pubmed,Embase,Cochrane Library,Web of Science,CNKI,CBM and Wanfang Data were searched.To search for cohort and case-control studies on risk factors for gangrenous cholecystitis,the search period was from established until June 2023.Review Manager 5.3 software was used for statistical analysis of the extracted data.Results:A total of 14 articles were included,involving a total of 11 risk factors,with a total sample size of 4 207.Meta analysis results showed systemic inflammatory reaction[OR =23.99,95% CI(12.46,46.19)],complicated coronary heart disease[OR = 21.50,95% CI(6.08,76.06)],gallbladder wall thickening[OR =17.31,95% CI(8.64,34.70)],fever[OR = 8.64,95% CI(4.60,16.21)],age[OR =7.89,95% CI(6.99,8.78)],white blood cell count[OR =5.73,95% CI(5.45,6.02)],complicated diabetes[OR =5.35,95% CI(4.10,6.98)],total bilirubin[OR =3.73,95% CI(2.33,5.99)],glutamic transaminase[OR =2.96,95% CI(1.96,4.48)]and male[OR =2.52,95% CI(2.00,3.17)]were risk factors for the occurrence of gangrenous cholecystitis(P＜0.05),while the presence of gallbladder stones[OR =0.12,95% CI(0.07,0.23)]was a protective factor for the occurrence of gangrenous cholecystitis(P＜0.05).Conclusion:Elderly men,diabetes,coronary heart disease,fever,elevated white blood cells and other systemic inflammatory reactions,combined with elevated alanine aminotransferase,ultrasonography showed that gallbladder wall thickening are risk factors for gangrene cholecystitis.
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