Effect of perioperative infusion of dexmedetomidine on postoperative renal function recovery in kidney transplant recipients:a systematic review and Meta analysis
Objective:There is a controversy regarding whether dexmedetomidine can improve renal function in postoperative kidney transplant recipients.Therefore,this study conducted a Meta-analysis on the relationship between perioperative infusion of dexmedetomidine and postoperative renal function recovery in kidney transplant recipients.Methods:The author searched clinical studies on the impact of perioperative infusion of DEX on postoperative renal function recovery in kidney transplant recipients from databases such as CNKI,Wanfang,Pubmed,Embase,Cochrane,Web of Science.The primary outcomes were delayed graft function(DGF),acute renal transplant rejection(ARTR)infection.Results:Seven studies were included in this Meta-analysis(including 6 randomized controlled trials and 1 retrospective study)with 1 223 patients.Compared with the control group,the experimental group showed significant improvements in delayed graft function[OR =0.71,95% CI(0.52,0.97)],infection(OR =0.51,95% CI(0.33,0.78)],postoperative day 2 creatinine(MD =-0.21,95% CI(-0.37,-0.06)]and length of hospital stay(MD =-0.87,95% CI(-1.61,-0.13)].Conclusion:Perioperative infusion of dexmedetomidine may help reduce ischemia-reperfusion injury in kidney transplant patients.
kidney transplantationdexmedetomidinedelayed recovery of graft functionacute kidney transplant rejectioncreatinine
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